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  4. Vero VRS1250: Interferometric AFM

Vero VRS1250: Interferometric AFM

2024 R&D 100, Frost & Sullivan Award Winner: Asylum Research's Vero Interferometric AFM
Vero AFM viewed from an angle.

The Vero VRS1250 is the world’s most technologically advanced AFM, featuring all three of Asylum’s most advanced AFM innovations: Quadrature Phase Differential Interferometry (QPDI), video-rate speed imaging, and blueDrive photothermal excitation.

Quadrature Phase Differential Interferometry:

  • Measures true tip displacement
  • Improves measurement sensitivity
  • Avoids crosstalk between vertical and in-plane forces
  • Is precisely calibrated by the wavelength of light

Vero VRS1250 features::

  • Video-rate imaging at up to 1250 lines/s (up to 45 frames/s)
  • Exceptional environmental control options
  • blueDrive photothermal excitation for simpler, more stable tapping mode imaging (included)


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The Vero VRS1250 builds on the ultra-high stability and performance of the Cypher VRS1250, while adding the benefits of Quadrature Phase Differential Interferometry (QPDI), which is unique to the next-generation Vero AFM Family.

Designed for ultra-high speed and spatial resolution

  • Select the ideal balance between imaging speed and imaging resolution for your experiments
  • Easily and consistently achieve higher resolution than other AFM’s
  • The Vero VRS1250 enables true video-rate imaging at rates up to 45 frames/second

Stable imaging keeps the “focus” on your sample

  • The Vero’s advanced design balances thermal expansion to virtually eliminate thermal drift
  • blueDrive photothermal excitation technology keeps imaging stable over long durations
  • Fully sealed sample cell keep imaging stable such that even delicate biomolecules can be observed without damage

Ease of use features make it easier to get great results

  • The Vero VRS1250 is designed with the same ease-of-use features as other Vero AFM’s
  • Motorized laser and detector alignment and simple probe loading make setup fast and easy
  • A fully sealed sample cell eliminates worries over leakage
  • Software includes features to easily process and export video-rate AFM movies for presentations and publications

All the flexibility and capabilities of Vero AFM's

  • The Vero VRS1250 supports all the functionality and associated benefits of the Vero ES environmental AFM
  • Options include sample heating and cooling and a complete range of operating modes
  • Vero VRS 1250 is much more than just a video-rate AFM. The platform is the ideal AFM for interdisciplinary research groups and shared imaging facilities

Measures true tip displacement

  • QPDI directly measures true tip displacement instead of cantilever angle, enabling improved quantification of many AFM measurements

Improves measurement sensitivity

  • QPDI lowers cantilever detection noise by a factor of up to 10× or more on many cantilevers, enabling improved measurement sensitivity

Avoids crosstalk between vertical and in-plane forces

  • Only QPDI measures pure vertical tip displacement, avoiding the large crosstalk between OBD vertical and lateral deflection signals

Is precisely calibrated by the wavelength of light

  • Interferometric detection avoids the assumptions and uncertainties associated with OBD calibration

Included Operating Modes

AM-FM Viscoelastic Mapping Mode
Contact mode
Contact Resonance Viscoelastic Mapping Mode 
DART PFM
Dual AC (Bimodal)
Dual AC Resonance Tracking (DART)
Electric force microscopy (EFM)
Force curves
Force mapping mode (force volume)
Force modulation
Frequency modulation
Kelvin probe force microscopy (KPFM)
Lateral force mode (LFM)
Loss tangent imaging
Magnetic force microscopy (MFM)
Nanolithography and nanomanipulation
Phase imaging
Piezoresponse force microscopy (PFM)
Switching spectroscopy PFM
Tapping mode (AC mode)
Tapping mode with digital Q control
Vector PFM

Optional Operating Modes

Fast Force Mapping Mode (FFM)
Conductive AFM (CAFM) with ORCA
Current mapping with FFM
Electrochemical Strain Microscopy (ESM)
Nanoscale Time Dependent Dielectric Breakdown (nanoTDDB)
Scanning tunneling microscopy (STM)

The Vero ES supports the same optional modes and accessories as the Cypher ES
Nanomechanical and Thermal Properties

Tools for quantitative characterization of visoelastic properties, including elastic modulus, loss modulus, loss tangent, as well as for measurement of thermal properties.


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Nanoelectrical and Electrochemical Properties

Tools for measuring electrical properties, including current, resistivity and permittivity, and more. Also includes PFM, STM, and EC-AFM techniques.

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Temperature and Other Environmental Control

Accessories for controlling temperature, the gas environments (gas/vapor composition or humidity), and operating under ultra-low oxygen and/or water levels in a glovebox.

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Operating in Liquid Environments

Accessories for operation in controlled liquid environments, with or without perfusion. The blueDrive photothermal excitation option is also under this accessory family.

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Support and Service Agreements

More than just an extended warranty, these packages provide peace of mind that your AFM is operating at peak performance and offer training opportunities for users.
Request Help with an Existing Asylum Research AFM
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Discover how to get more from Vero...

Vero Application Note:
Contact Mode Redefined
Vero Application Note:
Video-Rate AFM
Vero Application Note:
Improved AFM Precision
Vero Technical Note:
QPDI Explained

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