Cypher VRS1250 Video-Rate High Speed AFM

The Cypher VRS1250 is twice as fast as the first-generation Cypher VRS, scanning at up to 1250 lines/second. This enables either higher temporal resolution with frame rates up to 45 frames/second or increased spatial resolution by collecting more image pixels at lower frame rates. Combined with ultra-stable imaging, an easy-to-use fully sealed sample cell with perfusion capability, and a full range of modes and accessories, the Cypher VRS1250 is ready to help you achieve your most ambitious research goals.

Designed for both ultra-high speed and ultra-high resolution
Stable imaging allows dynamic events to be captured without drift or parameter adjustments
Ease of use features make setup and imaging simple
Includes all the added flexibility and capabilities of the Cypher ES research AFM

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Designed for ultra-high speed and spatial resolution

Select the ideal balance between imaging speed and imaging resolution for your experiments
Cypher AFM’s easily and consistently achieve higher resolution than other AFM’s
The Cypher VRS1250 enables true video-rate imaging at rates up to 45 frames/second

Stable imaging keeps the “focus” on your sample

The Cypher’s advanced design balances thermal expansion to virtually eliminate thermal drift
blueDrive photothermal excitation technology keeps imaging stable over long durations
Fully sealed sample cell keep imaging stable such that even delicate biomolecules can be observed without damage

Ease of use features make it easier to get great results

The Cypher VRS1250 is designed with the same ease-of-use features as other Cypher AFM’s
Motorized laser and detector alignment and simple probe loading make setup fast and easy
A fully sealed sample cell eliminates worries over leakage
Software includes features to easily process and export video-rate AFM movies for presentations and publications.

All the flexibility and capabilities of Cypher AFM's

The Cypher VRS1250 supports all the functionality and associated benefits of the Cypher ES environmental AFM
Options include sample heating and cooling and a complete range of operating modes.
Cypher VRS 1250 is much more than just a video-rate AFM. The platform is the ideal AFM for interdisciplinary research groups and shared imaging facilities.

Included Operating Modes

Contact mode
DART PFM
Dual AC
Dual AC Resonance Tracking (DART)
Electrostatic Force Microscopy (EFM)
Force curves
Force Mapping Mode (force volume)
Force modulation
Frequency modulation
Kelvin Probe Force Microscopy (KPFM)
Lateral Force Mode (LFM)
Loss tangent imaging
Magnetic Force Microscopy (MFM)
Nanolithography
Nanomanipulation
Phase imaging
Piezoresponse Force Microscopy (PFM)
Switching spectroscopy PFM
Tapping mode (AC mode)
Tapping mode with digital Q control
Vector PFM

Included because Cypher VRS comes with blueDrive

AM-FM Viscoelastic Mapping Mode
Contact Resonance Viscoelastic Mapping Mode

Optional Operating Modes

Conductive AFM (CAFM) with ORCA™ and Eclipse™ Mode
Current mapping with Fast Force Mapping
Electrochemical Strain Microscopy (ESM)
Fast Force Mapping Mode
High voltage PFM
Nanoscale Time Dependent Dielectric Breakdown (nanoTDDB)
Scanning Capacitance Microscopy (SCM)
Scanning Microwave Impedance Microscopy (sMIM)
Scanning Tunneling Microscopy (STM)

Nanomechanical and Thermal Properties

Tools for quantitative characterization of visoelastic properties, including elastic modulus, loss modulus, loss tangent, as well as for measurement of thermal properties

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Nanoelectrical and Electrochemical Properties

Tools for measuring electrical properties, including current, resistivity and permittivity, and more. Also includes PFM, STM, and EC-AFM techniques

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Temperature and Other Environmental Control

Accessories for controlling temperature, the gas environments (gas/vapor composition or humidity), and operating under ultra-low oxygen and/or water levels in a glovebox.

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Operating in Liquid Environments

Accessories for operation in controlled liquid environments, with or without perfusion. The blueDrive photothermal excitation option is also under this accessory family.

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Kalinin, S. V., Zhang, S., Valleti, M., Pyles, H., Baker, D., De Yoreo, J. J., & Ziatdinov, M. (2021). Disentangling Rotational Dynamics and Ordering Transitions in a System of Self-Organizing Protein Nanorods via Rotationally Invariant Latent Representations. ACS nano. https://doi.org/10.1021/acsnano.0c08914

Ziatdinov, M., Zhang, S., Dollar, O., Pfaendtner, J., Mundy, C. J., Li, X., ... & Kalinin, S. V. (2020). Quantifying the dynamics of protein self-organization using deep learning analysis of atomic force microscopy data. Nano Letters, 21(1), 158-165. https://dx.doi.org/10.1021/acs.nanolett.0c03447

Chen, J., Zhu, E., Liu, J., Zhang, S., Lin, Z., Duan, X., ... & De Yoreo, J. J. (2018). Building two-dimensional materials one row at a time: Avoiding the nucleation barrier. Science, 362(6419), 1135-1139. https://doi.org/10.1126/science.aau4146

Mao, X., Li, K., Liu, M., Wang, X., Zhao, T., An, B., ... & Wang, L. (2019). Directing curli polymerization with DNA origami nucleators. Nature communications, 10(1), 1-10. https://doi.org/10.1038/s41467-019-09369-6

Sigdel, K. P., Wilt, L. A., Marsh, B. P., Roberts, A. G., & King, G. M. (2018). The conformation and dynamics of P-glycoprotein in a lipid bilayer investigated by atomic force microscopy. Biochemical pharmacology, 156, 302-311. https://doi.org/10.1016/j.bcp.2018.08.017

Zhu, H., Wang, X., Cui, Y., Cai, J., Tian, F., Wang, J., & Qiu, H. (2019). Blooming of Block Copolymer Micelles into Complex Nanostructures on a Surface. Macromolecules, 52(9), 3479-3485. https://doi.org/10.1021/acs.macromol.9b00197

Ergo AFM Software

Ergo is the all-new Asylum AFM software, which complements our Igor Pro-based software. Ergo makes it simpler and faster to acquire high-quality AFM images.

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Support and Service Agreements

More than just an extended warranty, these packages provide peace of mind that your AFM is operating at peak performance and offer training opportunities for users.