Part of the Oxford Instruments Group


The Asylum Research MFP-3D-BIO sets the standard for integrating AFM and optical microscopy for bioscience research. It is the only bio-AFM that makes no compromises to AFM imaging resolution, force measurement performance, or application versatility while seamlessly integrating with a full range of optical techniques. This, along with unmatched support from Asylum experts, make it the best, most productive AFM to advance your research.

  • Uncompromised AFM performance integrated with optical microscopy
  • Simple, high-resolution imaging in liquid on soft biological samples
  • Performance leadership in force spectroscopy and force mechanics
  • Unmatched versatility to satisfy the diverse needs of multiple users
  • Unrivaled support from bio-AFM experts to get the results you need

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MFP-3D-BIO Brochure
MFP-3D Accessories Brochure

Uncompromised AFM performance integrated with optical microscopy

  • Illuminate or view with built-in top-down optics
  • Real-time optical navigation
  • High-quality objective allows easy viewing of opaque samples, laser alignment, and can be used as a condenser for brightfield or phase contrast illumination on transparent samples
  • Powerful real-time and offline rendering options including optical and AFM image overlays
  • Supports numerous optical techniques such as Brightfield, Phase Contrast, Epifluorescence, Confocal Microscopy, TIRF, FRET, FCS, FRAP, Ion Indicators (e.g. Ca2+ response)

Simple, high-resolution imaging in liquid on soft biological samples

  • Numerous environmental accessories for temperature control and simplifying imaging in liquid
  • Controlled gas or liquid environment options that are simple, safe and effective
  • SmartStart™ automatically detects and configures system components to get results quickly
  • ModeMaster™ automatically configures software for selected mode
  • GetReal™ automatically calibrates the cantilever spring constant and sensitivity
  • GetStarted™ automatically sets optimal parameters for tapping mode imaging

Performance leadership in force spectroscopy and force mechanics

  • Thermally-limited force resolution (<8 pm deflection noise tyical, <20 pm guaranteed)
  • Large Z range (15 µm standard, 40 µm extended Z option) accommodates demanding applications such as cell-cell and cell-substrate adhesion measurements
  • Choose between open-loop force curves with sensored Z for the ultimate in low noise performance or closed-loop Z for the most accurate velocity control
  • Force Mapping measures force-distance curves at a grid of points with automated fitting of indentation models for estimation of elastic modulus and automated adhesion/rupture force analysis

Unmatched versatility to satisfy the diverse needs of multiple users

  • Full suite of nanomechanical characterization modes available for measuring viscoelastic properties (storage/elastic modulus and loss modulus)
  • Unmatched range of nanoelectrical and electromechanical characterization modes
  • Unique accessories for applying external forces to a wide range of samples

Support that goes above and beyond your expectations

  • Includes a standard one-year comprehensive warranty
  • No-charge technical support and basic applications support for life
  • Affordable support agreements that offer extended warranties and advanced training

Included Operating Modes

Contact mode
Dual AC™
Dual AC Resonance Tracking (DART)
Electrostatic Force Microscopy (EFM)
Force curves
Force Mapping Mode (force volume)
Force modulation
Frequency modulation
Kelvin Probe Force Microscopy (KPFM)
Lateral Force Mode (LFM)
Loss tangent imaging
Magnetic Force Microscopy (MFM)
Phase imaging
Piezoresponse Force Microscopy (PFM)
Switching spectroscopy PFM
Tapping mode (AC mode)
Tapping mode with digital Q control
Vector PFM

Optional Operating Modes

AM-FM Viscoelastic Mapping Mode
Contact Resonance Viscoelastic Mapping Mode
Conductive AFM (CAFM) with ORCA™ and Eclipse™ Mode
High voltage PFM
Scanning Microwave Impedance Microscopy (sMIM)
Scanning Thermal Microscopy (SThM)
Scanning Tunneling Microscopy (STM)

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