Bottom-Up Nanofabrication with DNA Origami

A longstanding goal in the field of nanotechnology is not just the nanoscale characterization of materials but actually the engineered, controlled fabrication of nanoscale structures. Current approaches to nanofabrication can be loosely grouped into two categories: top-down and bottom-up. This application note describes bottom-up fabrication of complex nanostructures on DNA origami with subsequent characterization by Atomic Force Microscopy (AFM).

This app note describes:

• The early history of the assembly of DNA structures
• Applications of DNA Origami including biomaterial sciences, nanomedicine, photonics, nanorobotics and molecular computation
• How AFM can aid researchers in the attachment of molecules or nanoparticles to DNA Origami structures so their dynamics can be monitored over time

(Free download, compliments of Asylum Research, the Technology Leader in Atomic Force Microscopy)